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Peptide record

TPDB27130

Antibacterial Anticancer Toxicity modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
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TPDB27130
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 12-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XXKKWRKWLAKK
Physicochemical Analysis
C67H110N20O11
NDCEQGHIMFPSTYV
K
1371.74
11.85
6
0
4
+6
1.33
-1.683
40.83
Mammalian: Yeast: E.coli:
11000
801.90
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
5
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C67H110N20O11
1371.74
11.85
+6
1.33
-1.683
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
40 µM
Cytotoxic
50% Cell death | 40 | µM | target cell: Human diploid fibroblasts HFW

Target

Human diploid fibroblasts HFW

Source & Reference

NA
DBAASP
Novel antimicrobial peptides with high anticancer activity and selectivity. | PLoS One | 2015
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
10% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial peptides with high anticancer activity and selectivity. | PLoS One | 2015
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial peptides with high anticancer activity and selectivity. | PLoS One | 2015
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 May 13 10(5):e0126390.