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Peptide record

TPDB27115

Antibacterial Antifungal Toxicity modified_plain modified
2 amino acids
Basic Information
3D PDB MODEL
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TPDB27115
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 2-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
XX
Physicochemical Analysis
ARNDCEQGHILKMFPSTWYV
18.02
6.02
0
0
0
-0
0.00
0.000
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
18.02
6.02
-0
0.00
0.000
Evidence Records 23 records
Evidence 1 Activity

Activity

IC90
Toxicity
8.2 µM
Cytotoxic
IC90 | 8.2 | µM | target cell: Murine macrophage cells J774

Target

Murine macrophage cells J774

Source & Reference

NA
DBAASP
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening | ACS Chem Biol | 2012
Evidence 2 Activity

Activity

IC50
Toxicity
1.58±0.03 µM
Cytotoxic
IC50 | 1.58±0.03 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri. | Mar Drugs | 2014
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
4.896 µM
Cytotoxic
50% Cytotoxicity | 4.896 | µM | target cell: Vero E6 cells

Target

Vero E6 cells

Source & Reference

NA
DBAASP
Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro. | Virol J | 2009
Evidence 4 Activity

Activity

50% Cytotoxicity
Toxicity
1.609 µM
Cytotoxic
50% Cytotoxicity | 1.609 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro. | Virol J | 2009
Evidence 5 Activity

Activity

IC50
Toxicity
1.26±0.04 µM
Cytotoxic
IC50 | 1.26±0.04 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri. | Mar Drugs | 2014
Evidence 6 Activity

Activity

35% Hemolysis
Toxicity
31.2 µg/mL
Hemolytic Cytotoxic
35% Hemolysis | 31.2 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 7 Activity

Activity

70% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
70% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 8 Activity

Activity

LD50
Toxicity
30 µM
Cytotoxic
LD50 | 30 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines | ACS Med Chem Lett | 2022
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
31.2 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 31.2 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 11 Activity

Activity

LD50
Toxicity
63 µM
Cytotoxic
LD50 | 63 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines | ACS Med Chem Lett | 2022
Evidence 12 Activity

Activity

LD50
Toxicity
>512 µM
Cytotoxic
LD50 | >512 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines | ACS Med Chem Lett | 2022
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
31.2 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 31.2 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 14 Activity

Activity

10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
55.49 µM
Hemolytic Cytotoxic
50% Hemolysis | 55.49 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity of 2-(4-aminopiperidin-4-yl)acetic acid (β3,3-Pip) derivatives and its peptides conjugated with lauric acid through the side chain against methicillin-resistant Staphylococcus aureus (MRSA) | Microb Pathog | 2025
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
>1000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
750 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 750 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Systematic study of non-natural short cationic lipopeptides as novel broad-spectrum antimicrobial agents. | Chem Biol Drug Des | 2013
Evidence 19 Activity

Activity

0% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | Org Biomol Chem | 2012
Evidence 20 Activity

Activity

80% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
80% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | Org Biomol Chem | 2012
Evidence 21 Activity

Activity

84% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
84% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | Org Biomol Chem | 2012
Evidence 22 Activity

Activity

4% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | Org Biomol Chem | 2012
Evidence 23 Activity

Activity

51% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
51% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | Org Biomol Chem | 2012