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Peptide record

TPDB27113

Antibacterial Anticancer Toxicity modified_plain modified
20 amino acids
Basic Information
3D PDB MODEL
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TPDB27113
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 20-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XWXWXRPVYXPRPRPPHPRL
Physicochemical Analysis
C102H148N32O18
ANDCEQGIKMFST
P
2110.50
12.40
5
0
5
+4
1.77
-1.295
34.00
Mammalian: Yeast: E.coli:
12490
591.80
1
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
6
P
0
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 6 S: 0 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
20
C102H148N32O18
2110.50
12.40
+4
1.77
-1.295
Evidence Records 4 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
600 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 600 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016
Evidence 3 Activity

Activity

50% Cell death
Toxicity
640±50 µg/mL
Cytotoxic
50% Cell death | 640±50 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:1% Hemolysis=100µg/ml Human erythrocytes:2% Hemolysis=600µg/ml | Cytotoxicity: HEK293: 50% Cell death=640±50µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Dev Biol. 2016 May 10 4:39.