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Peptide record

TPDB26944

Antibacterial Anticancer Toxicity modified_plain modified
20 amino acids
Basic Information
3D PDB MODEL
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TPDB26944
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 20-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XRPDKPRPYLPRPRPPRPVR
Physicochemical Analysis
C106H176N38O23
ANCEQGHIMFSTW
P
2350.80
12.41
7
1
3
+6
9.25
-2.025
34.00
Mammalian: Yeast: E.coli:
1490
63.38
1
Residue Composition
number
0
A
6
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
8
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 8 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
20
C106H176N38O23
2350.80
12.41
+6
9.25
-2.025
Evidence Records 5 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
C-terminal modifications broaden the activity of the proline-rich antimicrobial peptide, Chex1-Arg20. | Aust J Chem | 2015
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
59.3±3.5 µM
Cytotoxic
50% Cytotoxicity | 59.3±3.5 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane. | Chem Biol | 2015
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane. | Chem Biol | 2015
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane. | Chem Biol | 2015