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Peptide record

TPDB26913

Antibacterial Toxicity modified_plain modified
30 amino acids
Basic Information
3D PDB MODEL
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TPDB26913
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 30-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XPFTXAQWFAIQHISPXTIAMXAINNYXWX
Physicochemical Analysis
C135H190N32O33S1
RDCEGLKV
AI
2821.25
7.77
1
0
14
+0
-4.78
0.233
65.33
Mammalian: Yeast: E.coli:
12490
442.71
8
Residue Composition
number
4
A
0
R
2
N
0
D
0
C
0
E
2
Q
0
G
1
H
4
I
0
L
0
K
1
M
2
F
2
P
1
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 4 L: 0 K: 0 M: 1 F: 2 P: 2 S: 1 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
30
C135H190N32O33S1
2821.25
7.77
+0
-4.78
0.233
Evidence Records 6 records
Evidence 1 Activity

Activity

10±2% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
10±2% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
113±8 µM
Cytotoxic
IC50 | 113±8 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 3 Activity

Activity

14±6% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
14±6% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 4 Activity

Activity

IC50
Toxicity
182±9 µM
Cytotoxic
IC50 | 182±9 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 5 Activity

Activity

43±1% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
43±1% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 6 Activity

Activity

IC50
Toxicity
7.6±0.7 µM
Cytotoxic
IC50 | 7.6±0.7 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021