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Peptide record

TPDB26897

Antibacterial Anticancer Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB26897
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XNNRPVYIPRPRPPHPRL
Physicochemical Analysis
C94H151N33O21
ADCEQGKMFSTW
P
2079.44
12.40
5
0
4
+4
6.00
-1.478
59.44
Mammalian: Yeast: E.coli:
1490
71.65
3
Residue Composition
number
0
A
4
R
2
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
1
L
0
K
0
M
0
F
6
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 6 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
18
C94H151N33O21
2079.44
12.40
+4
6.00
-1.478
Evidence Records 9 records
Evidence 1 Activity

Activity

1±0.2% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
1±0.2% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases. | Peptides | 2018
Evidence 2 Activity

Activity

1.3% Hemolysis
Toxicity
600 µg/mL
Hemolytic Cytotoxic
1.3% Hemolysis | 600 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic Peptides | PATENT US 9060513 B2 | 2010
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic Peptides | PATENT US 9060513 B2 | 2010
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human COS-7 cells

Target

Human COS-7 cells

Source & Reference

NA
DBAASP
Antibiotic Peptides | PATENT US 9060513 B2 | 2010
Evidence 5 Activity

Activity

1% Hemolysis
Toxicity
600 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 600 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic Peptides | PATENT US 9060513 B2 | 2010
Evidence 6 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens. | ACS Chem Biol | 2012
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016
Evidence 8 Activity

Activity

1% Hemolysis
Toxicity
600 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 600 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016
Evidence 9 Activity

Activity

50% Cell death
Toxicity
>600 µg/mL
Cytotoxic
50% Cell death | >600 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016