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Peptide record

TPDB26829

Antibacterial Antifungal Toxicity modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
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TPDB26829
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 11-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
XKLFKKILKYL
Physicochemical Analysis
C66H112N14O12
ARNDCEQGHMPSTWV
K
1293.70
10.64
4
0
6
+4
-0.10
0.164
141.82
Mammalian: Yeast: E.coli:
1490
115.17
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C66H112N14O12
1293.70
10.64
+4
-0.10
0.164
Evidence Records 13 records
Evidence 1 Activity

Activity

96±0.9% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
96±0.9% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 2 Activity

Activity

97±3% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
97±3% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 3 Activity

Activity

93±6% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
93±6% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 4 Activity

Activity

97±5% Hemolysis
Toxicity
375 µM
Hemolytic Cytotoxic
97±5% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 5 Activity

Activity

100±2% Hemolysis
Toxicity
250-375 µM
Hemolytic Cytotoxic
100±2% Hemolysis | 250-375 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of linear lipopeptides derived from BP100 towards plant pathogens. | PLoS One | 2018
Evidence 6 Activity

Activity

7% Hemolysis
Toxicity
1.25 µM
Hemolytic Cytotoxic
7% Hemolysis | 1.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 7 Activity

Activity

9% Hemolysis
Toxicity
2.5 µM
Hemolytic Cytotoxic
9% Hemolysis | 2.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 8 Activity

Activity

8% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
8% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 9 Activity

Activity

13% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
13% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 10 Activity

Activity

26% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
26% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 11 Activity

Activity

43% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
43% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 12 Activity

Activity

65% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
65% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016
Evidence 13 Activity

Activity

87% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
87% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scan and (2)H NMR analysis of the membrane-active peptide BP100 point to a distinct carpet mechanism of action. | Biochim Biophys Acta | 2016