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Peptide record

TPDB26819

Antibacterial Antifungal Toxicity modified_plain modified

4 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB26819

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb dbAMP

Sequence_Type

modified_plain

Has_Modification Yes

Description A 4-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.

Modification

Modified, details unspecified

Sequence

XKKK

FASTA

>TPDB26819|Antibacterial;Antifungal;Toxicity|length=4
XKKK

Formula C18H38N6O4

Absent Amino Acids ARNDCEQGHILMFPSTWYV

Common Amino Acids K

Mass 402.54

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +3

Boman Index 2.97

Hydrophobicity -2.925

Aliphatic Index 0.00

Half Life

Mammalian: Yeast: E.coli:

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C18H38N6O4

Mass

402.54

10.84

Net Charge

Boman Index

2.97

Hydrophobicity

-2.925

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 49.4±9.1 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 49.4±9.1 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vitro Evaluation of Cytotoxicity and Permeation Study on Lysine- and Arginine-Based Lipopeptides with Proven Antimicrobial Activity. | Molecules | 2017

Evidence 2 Activity

Activity

Activity Endpoint 30% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

30% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Biological and surface-active properties of double-chain cationic amino acid-based surfactants. | Amino Acids | 2014

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 18.79±0.62 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 18.79±0.62 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 4 Activity

Activity

Activity Endpoint 29% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

29% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 42.1±9.1 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 42.1±9.1 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In Vitro Evaluation of Cytotoxicity and Permeation Study on Lysine- and Arginine-Based Lipopeptides with Proven Antimicrobial Activity. | Molecules | 2017

Evidence 6 Activity

Activity

Activity Endpoint 40% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

40% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Biological and surface-active properties of double-chain cationic amino acid-based surfactants. | Amino Acids | 2014

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 31.09±9.3 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 31.09±9.3 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 8 Activity

Activity

Activity Endpoint 35% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

35% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 9 Activity

Activity

Activity Endpoint 1.03% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50-500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1.03% Hemolysis | 50-500 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 10 Activity

Activity

Activity Endpoint 1.53% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1.53% Hemolysis | 50 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 11 Activity

Activity

Activity Endpoint 2.07% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2.07% Hemolysis | 100 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 12 Activity

Activity

Activity Endpoint 22.44% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

22.44% Hemolysis | 500 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 13 Activity

Activity

Activity Endpoint 2.32% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2.32% Hemolysis | 50 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 14 Activity

Activity

Activity Endpoint 23.72% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

23.72% Hemolysis | 100 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 15 Activity

Activity

Activity Endpoint 96.40% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

96.40% Hemolysis | 500 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 16 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | 50 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 17 Activity

Activity

Activity Endpoint 42.10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

42.10% Hemolysis | 100 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 18 Activity

Activity

Activity Endpoint 97.97% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

97.97% Hemolysis | 500 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria. | Amino Acids | 2018

Evidence 19 Activity

Activity

Activity Endpoint 23% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

23% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 20 Activity

Activity

Activity Endpoint <5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<5% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Biological and surface-active properties of double-chain cationic amino acid-based surfactants. | Amino Acids | 2014

Evidence 21 Activity

Activity

Activity Endpoint 18% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

18% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 74.99±4.90 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 74.99±4.90 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 23 Activity

Activity

Activity Endpoint 25% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

25% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 43.28±6.48 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 43.28±6.48 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 25 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 26 Activity

Activity

Activity Endpoint 17% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

17% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 27 Activity

Activity

Activity Endpoint 32% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

32% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 1.16±0.64 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 1.16±0.64 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 29 Activity

Activity

Activity Endpoint 9% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

9% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 30 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 30.66±9.93 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 30.66±9.93 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 31 Activity

Activity

Activity Endpoint 13% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

13% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 32 Activity

Activity

Activity Endpoint 15% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

15% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 33 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of Self-Assembly on Antimicrobial Activity of Double-Chain Short Cationic Lipopeptides. | Bioorg Med Chem | 2019

Evidence 34 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity | Amino Acids | 2014