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Peptide record

TPDB26808

Antibacterial Toxicity modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
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TPDB26808
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 12-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XKAXWKXVKXVK
Physicochemical Analysis
C48H83N13O9
RNDCEQGHILMFPSTY
K
986.27
11.00
4
0
4
+4
2.08
-0.525
56.67
Mammalian: Yeast: E.coli:
5500
557.66
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
12
C48H83N13O9
986.27
11.00
+4
2.08
-0.525
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
5% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency. | Antimicrob Agents Chemother | 2011
Evidence 2 Activity

Activity

75% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
75% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency. | Antimicrob Agents Chemother | 2011