TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB26801

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 22-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Modification

Modified, details unspecified

Sequence

XIXIXIXRPVYXPRPRPPHPRL

FASTA

>TPDB26801|Antibacterial;Anticancer;Toxicity|length=22
XIXIXIXRPVYXPRPRPPHPRL

Formula C98H161N31O19

Absent Amino Acids ANDCEQGKMFSTW

Common Amino Acids P

Mass 2077.55

PI 12.40

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +4

Boman Index 4.54

Hydrophobicity -0.482

Aliphatic Index 84.09

Half Life

Mammalian: Yeast: E.coli:

Extinction Coefficient Cystines 1490

Absorbance 280nm 71.72

Polar Residues 1

number

0

A

4

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

3

I

1

L

0

K

0

M

0

F

6

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 3 L: 1 K: 0 M: 0 F: 0 P: 6 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

22

Formula

C98H161N31O19

Mass

2077.55

PI

12.40

Net Charge

+4

Boman Index

4.54

Hydrophobicity

-0.482

Evidence 1 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement >600 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | >600 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016

Evidence 2 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100-600 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 100-600 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa | Front Cell Dev Biol | 2016

Evidence 3 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes:0% Hemolysis=100-600µg/ml | Cytotoxicity: HEK293: 50% Cell death>600µg/ml

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Front Cell Dev Biol. 2016 May 10 4:39.