TPDB

3D PDB MODEL

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TPDB ID TPDB26795

Peptide_Name

Neuropeptide W-30

Activity

Antibacterial Neuropeptide

Activity_category_statistics

Anti-infective peptides Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 30-aa standard natural multi-activity (Antibacterial and Neuropeptide) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

WYKHVASPRYHTVGRAAGLLMGLRRSPYLW

FASTA

>TPDB26795|Antibacterial;Neuropeptide|length=30
WYKHVASPRYHTVGRAAGLLMGLRRSPYLW

Formula C165H249N49O37S1

Absent Amino Acids NDCEQIF

Common Amino Acids RL

Mass 3543.16

PI 11.33

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 15

Net Charge +5

Boman Index -1.88

Hydrophobicity -0.327

Aliphatic Index 81.33

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 15470

Absorbance 280nm 436.62

Polar Residues 6

number

3

A

4

R

0

N

0

D

0

C

0

E

0

Q

3

G

2

H

0

I

4

L

1

K

1

M

0

F

2

P

2

S

1

T

2

W

3

Y

2

V

Amino Acid Distribution

A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 2 I: 0 L: 4 K: 1 M: 1 F: 0 P: 2 S: 2 T: 1 W: 2 Y: 3 V: 2

Length

30

Formula

C165H249N49O37S1

Mass

3543.16

PI

11.33

Net Charge

+5

Boman Index

-1.88

Hydrophobicity

-0.327

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Escherichia coli ATCC11775

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC11775 (MIC 50 uM), P. aeruginosa PA01 (MIC 50 uM), P. aeruginosa PA14 (MIC 25 uM), S. aureus ATCC12600 (MIC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Pseudomonas aeruginosa PA01

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC11775 (MIC 50 uM), P. aeruginosa PA01 (MIC 50 uM), P. aeruginosa PA14 (MIC 25 uM), S. aureus ATCC12600 (MIC 3.12 uM), K-pneumoniae ATCC1338

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Pseudomonas aeruginosa PA14

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC11775 (MIC 50 uM), P. aeruginosa PA01 (MIC 50 uM), P. aeruginosa PA14 (MIC 25 uM), S. aureus ATCC12600 (MIC 3.12 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus ATCC12600

Source & Reference

Database Source NA

Other

Evidence Text

li ATCC11775 (MIC 50 uM), P. aeruginosa PA01 (MIC 50 uM), P. aeruginosa PA14 (MIC 25 uM), S. aureus ATCC12600 (MIC 3.12 uM), K-pneumoniae ATCC133883 (MIC >50 uM), A-baumannii ATCC19606 (MIC >50 uM), A-muciniphila

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism C. scindens ATCC35704

Source & Reference

Database Source NA

Other

Evidence Text

285 (MIC >50 uM), B-vulgatus ATCC8482 (MIC >50 uM), C-aerofaciens ATCC25986 (MIC >50 uM), C. scindens ATCC35704 (MIC 6.25 uM), B-thetaiotaomicron ATCC29148 (MIC >50 uM), B-uniformis ATCC8492 (MIC >50 uM), B-eggerthi

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptides B/W receptor type 1 Neuropeptides B/W receptor type 2

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Neuropeptide B/W

Receptor Lengths 328 333

Receptor Ligands NP06843 NP06845 NP06848 NP06851 NP06843 NP06845 NP06848 NP06851

Family

Neuropeptide B/W

Receptor_Lengths

328 333

Receptor_Ligands

NP06843 NP06845 NP06848 NP06851