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Peptide record

TPDB26769

Antibacterial Toxicity modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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TPDB26769
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 17-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
WWWAXYGLXLLXYXXWY
Physicochemical Analysis
C94H110N16O16
RNDCEQHIKMFPSTV
W
1720.00
5.84
0
0
11
-0
-12.06
0.312
74.71
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
26470
1538.95
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 3 V: 0
Chemical Descriptors
17
C94H110N16O16
1720.00
5.84
-0
-12.06
0.312
Evidence Records 2 records
Evidence 1 Activity

Activity

LD50
Toxicity
17±8 µM
Cytotoxic
LD50 | 17±8 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae. | Proc Natl Acad Sci U S A | 2020
Evidence 2 Activity

Activity

LD90
Toxicity
42±6 µM
Cytotoxic
LD90 | 42±6 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae. | Proc Natl Acad Sci U S A | 2020