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Peptide record

TPDB26762

Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB26762
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
WWRRWWRRWRRWWRRWWR
Physicochemical Analysis
C153H200N54O19
ANDCEQGHILKMFPSTYV
RW
3099.62
13.30
9
0
9
+9
-9.36
-2.700
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
49500
1596.97
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
9
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 9 Y: 0 V: 0
Chemical Descriptors
18
C153H200N54O19
3099.62
13.30
+9
-9.36
-2.700
Evidence Records 2 records
Evidence 1 Activity

Activity

LC50
Toxicity
9.6±0.2 µM
Cytotoxic
LC50 | 9.6±0.2 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. | Biochim Biophys Acta | 2015
Evidence 2 Activity

Activity

LC50
Toxicity
9.6
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Normal Human Dermal Fibroblasts (NHDF): LC50=9.6±0.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2015 Nov 1848(11 Pt A):2918-31.