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Peptide record

TPDB26755

Antibacterial Anticancer Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB26755
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
WWKKWXK
Physicochemical Analysis
C51H68N12O7
ARNDCEQGHILMFPSTYV
KW
961.18
10.84
3
0
3
+3
-2.58
-2.057
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
1716.64
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
7
C51H68N12O7
961.18
10.84
+3
-2.58
-2.057
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
53.2±21.2 µM
Cytotoxic
IC50 | 53.2±21.2 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide. | J Med Chem | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
53.2
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5: IC50=53.2 ± 21.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Apr 14 59(7):2918-27.