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Peptide record

TPDB26709

[WR]4 P1 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB26709
[WR]4 P1
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia and CPPsite3.0, with an available 3D structural model.
Sequence
WRWRWRWR
Physicochemical Analysis
C68H90N24O9
ANDCEQGHILKMFPSTYV
RW
1387.62
12.88
4
0
4
+4
-4.16
-2.700
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
1585.45
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H90N24O9
1387.62
12.88
+4
-4.16
-2.700
Free
L
Amphipathic Cationic and amphiphilic
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Raji Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphipathic
Synthetic
Methotrexate
In vitro
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphiphilic
Synthetic
Rhodamine123, Doxorubicin
In vitro
CCCCTTCCC
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
10% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues. | Acta Biomater | 2022
Evidence 4 Activity

Activity

10% Cell death
Toxicity
32 µM
Cytotoxic
10% Cell death | 32 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues. | Acta Biomater | 2022
Evidence 5 Activity

Activity

10% Cell death
Toxicity
64 µM
Cytotoxic
10% Cell death | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues. | Acta Biomater | 2022
Additional Detail Fields 1 fields
CCCCTTCCC