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Peptide record

TPDB26708

Antibacterial Antifungal Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB26708
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
WRWRWR
Physicochemical Analysis
C51H68N18O7
ANDCEQGHILKMFPSTYV
RW
1045.22
12.70
3
0
3
+3
-3.12
-2.700
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
1578.62
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
6
C51H68N18O7
1045.22
12.70
+3
-3.12
-2.700
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.8 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli KCTC 1682 (MIC 3.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aur
Evidence 2 Activity

Activity

MIC
Antibacterial
15.3 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP

Other

active against E. coli KCTC 1682 (MIC 3.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aureus KCTC 1621 (MIC 7.7 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
7.7 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP

Other

active against E. coli KCTC 1682 (MIC 3.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aureus KCTC 1621 (MIC 7.7 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
7.7 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP

Other

.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aureus KCTC 1621 (MIC 7.7 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
3.8 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli KCTC 1682 (MIC 3.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aur
Evidence 6 Activity

Activity

MIC
Antifungal
15.3 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP CAFPdb

Other

active against E. coli KCTC 1682 (MIC 3.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aureus KCTC 1621 (MIC 7.7 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
7.7 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP CAFPdb

Other

active against E. coli KCTC 1682 (MIC 3.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aureus KCTC 1621 (MIC 7.7 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
7.7 µM

Target

Staphylococcus aureus KCTC 1621

Source & Reference

dbAMP CAFPdb

Other

.8 uM), P. aeruginosa KCTC 1637 (MIC 15.3 uM), S. epidermidis KCTC 1917 (MIC 7.7 uM), and S. aureus KCTC 1621 (MIC 7.7 uM).
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. | Bioorg Med Chem Lett | 2013