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Peptide record

TPDB26704

Antibacterial Antifungal Toxicity standard

4 amino acids

3D PDB MODEL

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TPDB ID TPDB26704

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.

Sequence

WRWR

FASTA

>TPDB26704|Antibacterial;Antifungal;Toxicity|length=4
WRWR

Formula C34H46N12O5

Absent Amino Acids ANDCEQGHILKMFPSTYV

Common Amino Acids RW

Mass 702.82

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +2

Boman Index -2.08

Hydrophobicity -2.700

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 1565.13

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

Formula

C34H46N12O5

Mass

702.82

12.40

Net Charge

Boman Index

-2.08

Hydrophobicity

-2.700

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45.6 µM

Target

Target Organism Escherichia coli KCTC 1682

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against E. coli KCTC 1682 (MIC 45.6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. au

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45.6 µM

Target

Target Organism Pseudomonas aeruginosa KCTC 1637

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 45.6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. aureus KCTC 1621 (MIC 45.6 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 11.4 µM

Target

Target Organism Staphylococcus epidermidis KCTC 1917

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 45.6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. aureus KCTC 1621 (MIC 45.6 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45.6 µM

Target

Target Organism Staphylococcus aureus KCTC 1621

Source & Reference

Database Source dbAMP

Other

Evidence Text

6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. aureus KCTC 1621 (MIC 45.6 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45.6 µM

Target

Target Organism Escherichia coli KCTC 1682

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against E. coli KCTC 1682 (MIC 45.6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. au

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45.6 µM

Target

Target Organism Pseudomonas aeruginosa KCTC 1637

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 45.6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. aureus KCTC 1621 (MIC 45.6 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 11.4 µM

Target

Target Organism Staphylococcus epidermidis KCTC 1917

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

active against E. coli KCTC 1682 (MIC 45.6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. aureus KCTC 1621 (MIC 45.6 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45.6 µM

Target

Target Organism Staphylococcus aureus KCTC 1621

Source & Reference

Database Source dbAMP CAFPdb

Other

Evidence Text

6 uM), P. aeruginosa KCTC 1637 (MIC 45.6 uM), S. epidermidis KCTC 1917 (MIC 11.4 uM), and S. aureus KCTC 1621 (MIC 45.6 uM).

Evidence 9 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003

Evidence 10 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. | Bioorg Med Chem Lett | 2013