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Peptide record

TPDB26703

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Toxicity iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB26703
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides
Peptipedia iDPPIV
standard
No
A 3-aa standard natural multi-activity (Antibacterial, Toxicity, and iDPPIV) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.
Sequence
WRW
Physicochemical Analysis
C28H34N8O4
ANDCEQGHILKMFPSTYV
W
546.63
11.05
1
0
2
+1
-2.89
-2.100
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
2012.33
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
3
C28H34N8O4
546.63
11.05
+1
-2.89
-2.100
546.6194
546.2696
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003
Evidence 2 Activity

Activity

IC50
iDPPIV
487.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ito S., Kawarasaki Y.
Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV. Peptides, 54, 166-170
2014
Journal

Other

3
Additional Detail Fields 1 fields
3