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Peptide record

TPDB26697

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Toxicity iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB26697
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides
Peptipedia iDPPIV
standard
No
A 3-aa standard natural multi-activity (Antibacterial, Toxicity, and iDPPIV) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.
Sequence
WRT
Physicochemical Analysis
C21H31N7O5
ANDCEQGHILKMFPSYV
RTW
461.52
11.05
1
0
1
+1
-0.90
-2.033
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1191.71
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C21H31N7O5
461.52
11.05
+1
-0.90
-2.033
461.5135
461.2380
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
10% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues. | Acta Biomater | 2022
Evidence 2 Activity

Activity

10% Cell death
Toxicity
>256 µM
Cytotoxic
10% Cell death | >256 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues. | Acta Biomater | 2022
Evidence 3 Activity

Activity

10% Cell death
Toxicity
>256 µM
Cytotoxic
10% Cell death | >256 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues. | Acta Biomater | 2022
Evidence 4 Activity

Activity

IC50
iDPPIV
526.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ito S., Kawarasaki Y.
Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV. Peptides, 54, 166-170
2014
Journal

Other

3
Additional Detail Fields 1 fields
3