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Peptide record

TPDB26664

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB26664
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
WRAWAKIYHGVGKLLKGVGRW
Physicochemical Analysis
C120H181N35O23
NDCEQMFPST
G
2481.98
11.59
6
0
11
+5
-2.53
-0.257
92.86
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
17990
724.83
1
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
1
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
3
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 1 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 1 V: 2
Chemical Descriptors
21
C120H181N35O23
2481.98
11.59
+5
-2.53
-0.257
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
9.1 µM
Cytotoxic
EC50 | 9.1 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
193±9 µM
Hemolytic Cytotoxic
50% Hemolysis | 193±9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1685.