Back to search

Peptide record

TPDB26663

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Antifungal Hemolysis Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB26663
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Antifungal Hemolysis Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
WR
Physicochemical Analysis
C17H24N6O3
ANDCEQGHILKMFPSTYV
RW
360.42
11.05
1
0
1
+1
-1.04
-2.700
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1526.01
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C17H24N6O3
360.42
11.05
+1
-1.04
-2.700
360.4099
360.1905
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
19 µM
Hemolytic Cytotoxic
50% Hemolysis | 19 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin. | RSC Adv | 2015
Evidence 3 Activity

Activity

IC50
iDPPIV
37.80 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C17H24N6O3/c18-12(8-10-9-22-13-5-2-1-4-11(10)13)15(24)23-14(16(25)26)6-3-7-21-17(19)20/h1-2,4-5,9,12,14,22H,3,6-8,18H2,(H,23,24)(H,25,26)(H4,19,20,21)/t12-,14-/m0/s1 InChIKey=LCPVBXOHXMBLFW-JSGCOSHPSA-N Antagonist of Peroxisome proliferator-activated receptor γ (PPARγ) according to the BIOPEP-UWM database of biactive peptides the ChEMBL database
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
2