Back to search

Peptide record

TPDB26660

Antibacterial Antifungal Toxicity standard
127 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB26660
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept
standard
No
A 127-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
WPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL
Physicochemical Analysis
C648H1000N190O180S10
QPS
14652.83
9.13
23
7
44
+8
22.33
-0.543
68.35
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
18950
129.33
46
Residue Composition
number
8
A
6
R
8
N
6
D
8
C
1
E
10
Q
2
G
8
H
6
I
9
L
9
K
2
M
5
F
10
P
10
S
5
T
2
W
5
Y
7
V
Amino Acid Distribution
A: 8 R: 6 N: 8 D: 6 C: 8 E: 1 Q: 10 G: 2 H: 8 I: 6 L: 9 K: 9 M: 2 F: 5 P: 10 S: 10 T: 5 W: 2 Y: 5 V: 7
Chemical Descriptors
127
C648H1000N190O180S10
14652.83
9.13
+8
22.33
-0.543
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

In 2014, the Spencer lab demonstrated its antimicrobial activity against uropathogenic E. coli (UPEC), E. faecalis, and S. saprophyticus at micromolar concentrations, comparable to RNase 7.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

In 2014, the Spencer lab demonstrated its antimicrobial activity against uropathogenic E. coli (UPEC), E. faecalis, and S. saprophyticus at micromolar concentrations, comparable to RNase 7.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>20 µM
Hemolytic Cytotoxic
50% Hemolysis | >20 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation. | Int J Mol Sci | 2016