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Peptide record

TPDB26583

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB26583
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
WILLLLKKFLKKL
Physicochemical Analysis
C86H146N18O14
ARNDCEQGHMPSTYV
L
1656.22
11.00
4
0
9
+4
-2.69
1.046
210.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
332.08
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
6
L
4
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 6 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C86H146N18O14
1656.22
11.00
+4
-2.69
1.046
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against E. coli (MIC 6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 6.25 uM), E. cloacae (MIC12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aur
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Enterobacter aerogenes

Source & Reference

NA

Other

active against E. coli (MIC 6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 6.25 uM), E. cloacae (MIC12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Enterobacter cloacae

Source & Reference

NA

Other

against E. coli (MIC 6. 25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 6.25 uM), E. cloacae (MIC12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis
Evidence 4 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

25 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 6.25 uM), E. cloacae (MIC12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 0.78 uM), E. faecalis (
Evidence 5 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

13 uM), E. aerogenes (MIC 6.25 uM), E. cloacae (MIC12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 0.78 uM), E. faecalis (MIC1.56 uM), E. faecium (
Evidence 6 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

B. cereus

Source & Reference

NA

Other

6.25 uM), E. cloacae (MIC12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 0.78 uM), E. faecalis (MIC1.56 uM), E. faecium (MIC3.13 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

S. lactis

Source & Reference

NA

Other

C12.5 uM), K. pneumoniae (MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 0.78 uM), E. faecalis (MIC1.56 uM), E. faecium (MIC3.13 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

(MIC 3.13 uM), S. aureus (MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 0.78 uM), E. faecalis (MIC1.56 uM), E. faecium (MIC3.13 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

E. faecium

Source & Reference

NA

Other

MIC 3.13 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 0.78 uM), E. faecalis (MIC1.56 uM), E. faecium (MIC3.13 uM).
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022