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Peptide record

TPDB26538

Antibacterial Antifungal standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB26538
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 32-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
WKSESVCTPGCVTGILQTCFLQSITCNCRLSK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C149H245N41O46S5
ADHMY
C
3507.13
8.14
3
1
9
+2
0.88
0.266
79.06
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5750
1.64
16
Residue Composition
number
0
A
1
R
1
N
0
D
5
C
1
E
2
Q
2
G
0
H
2
I
3
L
2
K
0
M
1
F
1
P
4
S
4
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 5 E: 1 Q: 2 G: 2 H: 0 I: 2 L: 3 K: 2 M: 0 F: 1 P: 1 S: 4 T: 4 W: 1 Y: 0 V: 2
Chemical Descriptors
32 reviewed residue count
C149H245N41O46S5 sequence-only estimate (linear, free termini)
3507.13 sequence-only estimate (linear, free termini)
8.14 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.88 sequence-only estimate (linear, free termini)
0.266 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against Gram-positive bacteria including B. amyloliquefaciens ATCC 15841, or L-S60, or L-H15 (diameter of inhibition zone: 16.0-16.2 mm), B. cereus ATCC 14579 (16.4 mm), L. lactis NZ9000 or MG1363 (9.1-9.4 mm), L. plantarum S-35 or gamma-35 (10.3-11 mm), S. aureus ATCC 29213, or 43300, or 26112 (16.1-16.4 mm), and E. faecalis ATCC 29212 (16.2 mm), or 51299 (8.2 mm), or M2 (6.3 mm) but not active against E.coli DH5alpha, or BL21, or BW25113, or JM109 (0 mm), and S.cerevisiae (0 mm), P.pastoris GS115 (0 mm). Also show great biophysical characteristics such as thermostability, pH-insensitive, resistance to chemical reagents, and sensitivity to various human proteases. Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against Gram-positive bacteria including B. amyloliquefaciens ATCC 15841, or L-S60, or L-H15 (diameter of inhibition zone: 16.0-16.2 mm), B. cereus ATCC 14579 (16.4 mm), L. lactis NZ9000 or MG1363 (9.1-9.4 mm), L. plantarum S-35 or gamma-35 (10.3-11 mm), S. aureus ATCC 29213, or 43300, or 26112 (16.1-16.4 mm), and E. faecalis ATCC 29212 (16.2 mm), or 51299 (8.2 mm), or M2 (6.3 mm) but not active against E.coli DH5alpha, or BL21, or BW25113, or JM109 (0 mm), and S.cerevisiae (0 mm), P.pastoris GS115 (0 mm). Also show great biophysical characteristics such as thermostability, pH-insensitive, resistance to chemical reagents, and sensitivity to various human proteases. Updated 7/2021