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Peptide record

TPDB26537

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB26537
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
WKRFHPFRVVRKIFRRRIKR
Physicochemical Analysis
C131H213N47O21
ANDCEQGLMSTY
R
2782.43
13.18
11
0
8
+10
4.33
-1.155
68.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
197.67
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
0
L
3
K
0
M
3
F
1
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 0 K: 3 M: 0 F: 3 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
20
C131H213N47O21
2782.43
13.18
+10
4.33
-1.155
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. subtilis ATCC 6051

Source & Reference

NA

Other

active against B. subtilis ATCC 6051 (MIC 2 ug/ml), E. coli KCCM 11234 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), S. aureus KCCM
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Escherichia coli KCCM 11234

Source & Reference

NA

Other

active against B. subtilis ATCC 6051 (MIC 2 ug/ml), E. coli KCCM 11234 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), S. aureus KCCM 11335 (MIC 1 ug/ml), and S. epider
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

active against B. subtilis ATCC 6051 (MIC 2 ug/ml), E. coli KCCM 11234 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), S. aureus KCCM 11335 (MIC 1 ug/ml), and S. epidermidis ATCC 12228 (MIC 2 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

Staphylococcus aureus KCCM 11335

Source & Reference

NA

Other

1 (MIC 2 ug/ml), E. coli KCCM 11234 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), S. aureus KCCM 11335 (MIC 1 ug/ml), and S. epidermidis ATCC 12228 (MIC 2 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

8 ug/ml), P. aeruginosa ATCC 9027 (MIC 4 ug/ml), S. aureus KCCM 11335 (MIC 1 ug/ml), and S. epidermidis ATCC 12228 (MIC 2 ug/ml).
Evidence 6 Activity

Activity

IC50
Toxicity
>256 µg/mL
Cytotoxic
IC50 | >256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Identifying novel antimicrobial peptides from venom gland of spider Pardosa astrigera by deep multi-task learning | Front Microbiol | 2022
Evidence 7 Activity

Activity

IC50
Toxicity
140.3 µg/mL
Cytotoxic
IC50 | 140.3 | µg/mL | target cell: Human normal astrocytes

Target

Human normal astrocytes

Source & Reference

NA
DBAASP
Identifying novel antimicrobial peptides from venom gland of spider Pardosa astrigera by deep multi-task learning | Front Microbiol | 2022
Evidence 8 Activity

Activity

IC50
Toxicity
178.8 µg/mL
Cytotoxic
IC50 | 178.8 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Identifying novel antimicrobial peptides from venom gland of spider Pardosa astrigera by deep multi-task learning | Front Microbiol | 2022
Evidence 9 Activity

Activity

<3% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
<3% Hemolysis | 16 | µg/mL | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Identifying novel antimicrobial peptides from venom gland of spider Pardosa astrigera by deep multi-task learning | Front Microbiol | 2022
Evidence 10 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2022 Aug 24 13:971503.