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Peptide record

TPDB26526

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Anticancer Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB26526
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Anticancer Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Toxicity, and other sources) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.
Sequence
WK
Physicochemical Analysis
C17H24N4O3
ARNDCEQGHILMFPSTYV
KW
332.40
10.10
1
0
1
+1
-0.86
-2.400
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1654.62
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C17H24N4O3
332.40
10.10
+1
-0.86
-2.400
332.3965
332.1843
Evidence Records 5 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
0% Hemolysis | 1000 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 2 Activity

Activity

<10% Hemolysis
Toxicity
10000 µM
Hemolytic Cytotoxic
<10% Hemolysis | 10000 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
1000 µM
Cytotoxic
0% Cytotoxicity | 1000 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2022 Jan 19 20(2):92.
Evidence 5 Activity

Activity

IC50
iDPPIV
40.60 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51
2014
Journal

Other

2
Additional Detail Fields 1 fields
2