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Peptide record

TPDB26518

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Anticancer Antifungal Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB26518
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Anticancer Antifungal Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
WI
Physicochemical Analysis
C17H23N3O3
ARNDCEQGHLKMFPSTYV
IW
317.39
6.02
0
0
2
-0
-2.16
1.800
195.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1732.90
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C17H23N3O3
317.39
6.02
-0
-2.16
1.800
317.3819
317.1734
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. | Peptides | 2014
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. | Peptides | 2014
Evidence 3 Activity

Activity

IC50
iDPPIV
138.70 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51
2014
Journal

Other

2
Additional Detail Fields 1 fields
2