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Peptide record

TPDB26501

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) WF Antibacterial Anticancer Antifungal Toxicity iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB26501
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) WF
Antibacterial Anticancer Antifungal Toxicity iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Self-assembling and biomaterial peptides
Peptipedia CancerPPD 2.0 CAFPdb dbAMP iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.
Sequence
WF
Physicochemical Analysis
C20H21N3O3
ARNDCEQGHILKMPSTYV
FW
351.41
6.02
0
0
2
-0
-2.98
0.950
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1565.15
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C20H21N3O3
351.41
6.02
-0
-2.98
0.950
351.3982
351.1578
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

27841381
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
Selfassembly; Nanostructure=Nanoparticles
TEM and SEM
Selfassembly
Evidence Records 5 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. | Peptides | 2014
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. | Peptides | 2014
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2020 Aug 12 25(16):3676.
Evidence 4 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51
2014
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1c[nH]c2c1cccc2 InChI=1S/C20H21N3O3/c21-16(11-14-12-22-17-9-5-4-8-15(14)17)19(24)23-18(20(25)26)10-13-6-2-1-3-7-13/h1-9,12,16,18,22H,10-11,21H2,(H,23,24)(H,25,26)/t16-,18-/m0/s1 InChIKey: IMMPMHKLUUZKAZ-WMZOPIPTSA-N Bitter peptide according to BIOPEP database of sensory peptides and amino acids
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
TEM and SEM
27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1891 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 5 fields
None specified
SAPdb ID 1891 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
2
27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly