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Peptide record

TPDB26476

Antibacterial Anticancer Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB26476
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
VXXFPWWWPFLXX
Physicochemical Analysis
C72H84N12O10
ARNDCEQGHIKMSTY
W
1277.53
6.02
0
0
7
-0
-7.40
0.592
52.31
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
1291.55
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
2
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C72H84N12O10
1277.53
6.02
-0
-7.40
0.592
Evidence Records 15 records
Evidence 1 Activity

Activity

IC50
Toxicity
>=65 µM
Cytotoxic
IC50 | >=65 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>=65 µM
Hemolytic Cytotoxic
50% Hemolysis | >=65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
9.3 µM
Cytotoxic
IC50 | 9.3 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
34.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 34.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities. | Biochim Biophys Acta | 2011
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
50% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities. | Biochim Biophys Acta | 2011
Evidence 7 Activity

Activity

IC50
Toxicity
19.4 µM
Cytotoxic
IC50 | 19.4 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
120 µM
Hemolytic Cytotoxic
10% Hemolysis | 120 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities. | Biochim Biophys Acta | 2011
Evidence 9 Activity

Activity

IC50
Toxicity
38.1 µM
Cytotoxic
IC50 | 38.1 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
50% Hemolysis | 60 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities. | Biochim Biophys Acta | 2011
Evidence 11 Activity

Activity

IC50
Toxicity
25.8 µM
Cytotoxic
IC50 | 25.8 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 12 Activity

Activity

IC50
Toxicity
34.6 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50=34.6 µM | Cytotoxicity: PBMC: IC50=9.3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.
Evidence 13 Activity

Activity

IC50
Toxicity
65 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50 ≥ 65 µM | Cytotoxicity: PBMC: IC50=25.8 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.
Evidence 14 Activity

Activity

IC50
Toxicity
65 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50 ≥ 65 µM | Cytotoxicity: PBMC: IC50 ≥ 65 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.
Evidence 15 Activity

Activity

IC50
Toxicity
41.3 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50=41.3 µM | Cytotoxicity: PBMC: IC50=19.4 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.