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Peptide record

TPDB26453

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Anticancer Antifungal Antihypertensive Bitter Hemolysis Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB26453
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Anticancer Antifungal Antihypertensive Bitter Hemolysis Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Food sensory peptides
Peptipedia CAFPdb dbAMP AHTPDB Tastepeptides-Meta PD_Hemolysis iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
WE
Physicochemical Analysis
C16H19N3O5
ARNDCQGHILKMFPSTYV
EW
333.34
3.29
0
1
1
-1
0.17
-2.200
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1649.95
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C16H19N3O5
333.34
3.29
-1
0.17
-2.200
333.3384
333.1320
Evidence Records 7 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
0% Hemolysis | 1000 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 2 Activity

Activity

17% Hemolysis
Toxicity
10000 µM
Hemolytic Cytotoxic
17% Hemolysis | 10000 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 3 Activity

Activity

13% Cytotoxicity
Toxicity
1000 µM
Cytotoxic
13% Cytotoxicity | 1000 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >>100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small lipopeptides possess anti-biofilm capability comparable to daptomycin and vancomycin. | RSC Adv | 2015
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2022 Jan 19 20(2):91.
Evidence 6 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1 InChIKey=PWIQCLSQVQBOQV-AAEUAGOBSA-N PPARγ antagonist according to the BIOPEP-UWM database of bioactive peptides the ChEMBL database PPARα agonist according to the BIOPEP-UWM database of bioactive peptides the ChEMBL database Hypolipidemic peptide according to the BIOPEP-UWM database of bioactive peptides the ChEMBL database Hypocholesterolemic peptide according to the ChEMBL database
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
2