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Peptide record

TPDB26386

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB26386
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, AHTPDB, and other sources, with an available 3D structural model.
Sequence
WA
Physicochemical Analysis
C14H17N3O3
RNDCEQGHILKMFPSTYV
AW
275.31
6.02
0
0
2
-0
-2.02
0.450
50.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1997.77
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C14H17N3O3
275.31
6.02
-0
-2.02
0.450
275.3024
275.1266
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
275.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](C)C(=O)O InChI=1S/C14H17N3O3/c1-8(14(19)20)17-13(18)11(15)6-9-7-16-12-5-3-2-4-10(9)12/h2-5,7-8,11,16H,6,15H2,1H3,(H,17,18)(H,19,20)/t8-,11-/m0/s1 InChIKey: OHGNSVACHBZKSS-KWQFWETISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8528) the EROP-Moscow database Peptide activating ubiquitin-mediated proteolysis according to the BIOPEP-UWM database of bioactive peptides (ID 4007) the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
275.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](C)C(=O)O InChI=1S/C14H17N3O3/c1-8(14(19)20)17-13(18)11(15)6-9-7-16-12-5-3-2-4-10(9)12/h2-5,7-8,11,16H,6,15H2,1H3,(H,17,18)(H,19,20)/t8-,11-/m0/s1 InChIKey: OHGNSVACHBZKSS-KWQFWETISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8528) the EROP-Moscow database Peptide activating ubiquitin-mediated proteolysis according to the BIOPEP-UWM database of bioactive peptides (ID 4007) the EROP-Moscow database
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
0% Hemolysis | 1000 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 4 Activity

Activity

20% Hemolysis
Toxicity
10000 µM
Hemolytic Cytotoxic
20% Hemolysis | 10000 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 5 Activity

Activity

35% Cytotoxicity
Toxicity
1000 µM
Cytotoxic
35% Cytotoxicity | 1000 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides. | Mar Drugs | 2022
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2022 Jan 19 20(2):85.
Evidence 7 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hikida A., Ito K., Motoyama T., Kato R., Kawarasaki Y.
Systematic analysis of a dipeptide library for inhibitor development using human dipeptidyl peptidase IV produced by a Saccharomyces cerevisiae expression system. Biochemical and Biophysical Research Communications 430, 1217-1222, 2013
2013
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](C)C(=O)O InChI=1S/C14H17N3O3/c1-8(14(19)20)17-13(18)11(15)6-9-7-16-12-5-3-2-4-10(9)12/h2-5,7-8,11,16H,6,15H2,1H3,(H,17,18)(H,19,20)/t8-,11-/m0/s1 InChIKey: OHGNSVACHBZKSS-KWQFWETISA-N Peptide activating ubiquitin-mediated proteolysis according to the BIOPEP-UWM database of bioactive peptides (ID 4007) the EROP-Moscow database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 9089) the EROP-Moscow database
Additional Detail Fields 1 fields
2