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Peptide record

TPDB26371

Antibacterial Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB26371
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
VWKRWVVRKWKWVKKKVKKK
Physicochemical Analysis
C135H219N39O21
ANDCEQGHILMFPSTY
K
2724.47
12.48
11
0
9
+11
3.48
-1.335
72.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
22000
807.50
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
9
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
5
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 5
Chemical Descriptors
20
C135H219N39O21
2724.47
12.48
+11
3.48
-1.335
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
57.24±5.2 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 57.24±5.2 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019
Evidence 2 Activity

Activity

40% Killing
Toxicity
640 µg/mL
Cytotoxic
40% Killing | 640 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis