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Peptide record

TPDB26367

Antibacterial Antifungal Toxicity standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB26367
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept
standard
No
A 70-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
VVSKLGWTGINIGTANALIGALMTGSDIWTAISVAGLAFGGGIGTAISTIGRKAIMEMVEKVGKKKAAQW
Physicochemical Analysis
C319H527N85O90S3
CHPY
G
7089.39
10.53
7
3
35
+4
1.17
0.563
107.43
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
232.74
13
Residue Composition
number
10
A
1
R
2
N
1
D
0
C
2
E
1
Q
12
G
0
H
9
I
4
L
6
K
3
M
1
F
0
P
4
S
6
T
3
W
0
Y
5
V
Amino Acid Distribution
A: 10 R: 1 N: 2 D: 1 C: 0 E: 2 Q: 1 G: 12 H: 0 I: 9 L: 4 K: 6 M: 3 F: 1 P: 0 S: 4 T: 6 W: 3 Y: 0 V: 5
Chemical Descriptors
70
C319H527N85O90S3
7089.39
10.53
+4
1.17
0.563
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.29-0.39 µM

Target

B. cereus ATCC 14579 and 49064

Source & Reference

NA

Other

Inhibited the growth of B. cereus ATCC 14579 on solid medium. MIC: B. cereus ATCC 14579 and 49064 (MIC 0.29-0.39 uM) and L. monocytogenes strains LM201, CMC54002, ATCC 19115 (MIC 0.39-0.78 uM), B. amyloliqu
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

B. amyloliquefaciens X1

Source & Reference

NA

Other

.29-0.39 uM) and L. monocytogenes strains LM201, CMC54002, ATCC 19115 (MIC 0.39-0.78 uM), B. amyloliquefaciens X1 (MIC6.25 uM), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B.
Evidence 3 Activity

Activity

MIC
Antibacterial
0.39-0.78 µM

Target

B. thuringiensis BMB171 or YBT-1518

Source & Reference

NA

Other

ins LM201, CMC54002, ATCC 19115 (MIC 0.39-0.78 uM), B. amyloliquefaciens X1 (MIC6.25 uM), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 u
Evidence 4 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

B. firmus DS-1

Source & Reference

NA

Other

myloliquefaciens X1 (MIC6.25 uM), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 uM), and E. faecalis ATCC29212/
Evidence 5 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

B. subtilis 168

Source & Reference

NA

Other

M), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 uM), and E. faecalis ATCC29212/ATCC51299 (MIC 6.25-12.5 uM). N
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

B. pumilus SCG1

Source & Reference

NA

Other

YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 uM), and E. faecalis ATCC29212/ATCC51299 (MIC 6.25-12.5 uM). Not active against S.aureus ATCC
Evidence 7 Activity

Activity

MIC
Antifungal
0.29-0.39 µM

Target

B. cereus ATCC 14579 and 49064

Source & Reference

Antifungipept

Other

Inhibited the growth of B. cereus ATCC 14579 on solid medium. MIC: B. cereus ATCC 14579 and 49064 (MIC 0.29-0.39 uM) and L. monocytogenes strains LM201, CMC54002, ATCC 19115 (MIC 0.39-0.78 uM), B. amyloliqu
Evidence 8 Activity

Activity

MIC
Antifungal
6.25 µM

Target

B. amyloliquefaciens X1

Source & Reference

Antifungipept

Other

.29-0.39 uM) and L. monocytogenes strains LM201, CMC54002, ATCC 19115 (MIC 0.39-0.78 uM), B. amyloliquefaciens X1 (MIC6.25 uM), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B.
Evidence 9 Activity

Activity

MIC
Antifungal
0.39-0.78 µM

Target

B. thuringiensis BMB171 or YBT-1518

Source & Reference

Antifungipept

Other

ins LM201, CMC54002, ATCC 19115 (MIC 0.39-0.78 uM), B. amyloliquefaciens X1 (MIC6.25 uM), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 u
Evidence 10 Activity

Activity

MIC
Antifungal
3.13 µM

Target

B. firmus DS-1

Source & Reference

Antifungipept

Other

myloliquefaciens X1 (MIC6.25 uM), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 uM), and E. faecalis ATCC29212/
Evidence 11 Activity

Activity

MIC
Antifungal
1.56 µM

Target

B. subtilis 168

Source & Reference

Antifungipept

Other

M), B. thuringiensis BMB171 or YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 uM), and E. faecalis ATCC29212/ATCC51299 (MIC 6.25-12.5 uM). N
Evidence 12 Activity

Activity

MIC
Antifungal
12.5 µM

Target

B. pumilus SCG1

Source & Reference

Antifungipept

Other

YBT-1518 (MIC 0.39-0.78 uM), B. firmus DS-1 (MIC 3.13 uM), B. subtilis 168 (MIC 1.56 uM), B. pumilus SCG1 (MIC 12.5 uM), and E. faecalis ATCC29212/ATCC51299 (MIC 6.25-12.5 uM). Not active against S.aureus ATCC
Evidence 13 Activity

Activity

1% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
1% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Silico Analysis Highlights the Diversity and Novelty of Circular Bacteriocins in Sequenced Microbial Genomes. | mSystems | 2020