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Peptide record

TPDB26325

ACE inhibitor D-Val-L-Val-GCV (DLGCV) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-Val-D-Val-GCV (LDGCV) L-Val-L-Val-GCV (LLGCV) Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Umami iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB26325
ACE inhibitor D-Val-L-Val-GCV (DLGCV) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-Val-D-Val-GCV (LDGCV) L-Val-L-Val-GCV (LLGCV)
Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Umami iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia SATPdb CAFPdb AHTPDB Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, SATPdb, CAFPdb, and other sources, with an available 3D structural model.
Sequence
VV
Physicochemical Analysis
C10H20N2O3
ARNDCEQGHILKMFPSTWY
V
216.28
6.02
0
0
2
-0
0.14
4.200
290.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
2
C10H20N2O3
216.28
6.02
-0
0.14
4.200
216.2766
216.1469
Self-Assembly Information 6 records
Record 1 Selfassembly

Source

25564964
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
Selfassembly; Nanostructure=Nanoparticles; Trigger=temperature: Room temperature; solvent: thermosensitive PLGA-PEG-PLGA polymer gel; concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
double-emulsion solvent evaporation technique
Selfassembly
Record 2 Selfassembly

Source

25564964
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
Selfassembly; Nanostructure=Nanoparticles; Trigger=temperature: Room temperature; solvent: thermosensitive PLGA-PEG-PLGA polymer gel; concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
double-emulsion solvent evaporation technique
Selfassembly
Record 3 Selfassembly

Source

25564964
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
Selfassembly; Nanostructure=Nanoparticles; Trigger=temperature: Room temperature; solvent: thermosensitive PLGA-PEG-PLGA polymer gel; concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
double-emulsion solvent evaporation technique
Selfassembly
Record 4 Selfassembly

Source

25775276
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
Selfassembly; Nanostructure=Nanoparticles; Trigger=temperature: Room temperature; solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA); concentration: 2.0% (w/v)
double emulsion method
Selfassembly
Record 5 Selfassembly

Source

25775276
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
Selfassembly; Nanostructure=Nanoparticles; Trigger=temperature: Room temperature; solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA); concentration: 2.0% (w/v)
double emulsion method
Selfassembly
Record 6 Selfassembly

Source

25775276
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
Selfassembly; Nanostructure=Nanoparticles; Trigger=temperature: Room temperature; solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA); concentration: 2.0% (w/v)
double emulsion method
Selfassembly
Evidence Records 8 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Moreno-Mariscal C., Carrera-Alvarado G., Mora L., Toldrá F.
Neprilysin (NEP) and Angiotensin Converting Enzyme-I (ACE-I) inhibitory dipeptides from chicken carcass hydrolysates. LWT, 221, 117591, 2025
2025
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C10H20N2O3/c1-5(2)7(11)9(13)12-8(6(3)4)10(14)15/h5-8H,11H2,1-4H3,(H,12,13)(H,14,15)/t7-,8-/m0/s1 InChIKey=KRNYOVHEKOBTEF-YUMQZZPRSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3183) Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BIOPEP-UWM database of bioactive peptides (ID 10797) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 259) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 328) the ChEMBL database the PubChem database
Evidence 2 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Bella A. M., Erickson R. H. Jr., Kim Y. S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV:kinetic properties and substrate specifities of the purified enzyme. Arch. Biochem. Biophys., 218 (1), 156-162 (1982)
1982
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C10H20N2O3/c1-5(2)7(11)9(13)12-8(6(3)4)10(14)15/h5-8H,11H2,1-4H3,(H,12,13)(H,14,15)/t7-,8-/m0/s1 InChIKey: KRNYOVHEKOBTEF-YUMQZZPRSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Inhibitor of Tripeptidyl Peptidase 2 (EC 3.4.14.10) (MEROPS ID S08.090) according to the BRENDA database the ChEMBL database the PubChem database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 259) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 328) the ChEMBL database the PubChem database
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
double-emulsion solvent evaporation technique
25564964
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1809 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
double-emulsion solvent evaporation technique
25564964
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1810 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution
double-emulsion solvent evaporation technique
25564964
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1811 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 6 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
double emulsion method
25775276
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1812 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 7 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
double emulsion method
25775276
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1813 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Evidence 8 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles Trigger=temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: Room temperature solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
double emulsion method
25775276
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1814 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
temperature: Room temperature solvent: thermosensitive PLGA-PEG-PLGA polymer gel concentration: 23% w/w PLGA-PEG-PLGA aqueous solution solvent: Poly(D,L-lactic-co-glycolic acid) (PLGA) concentration: 2.0% (w/v)
None specified
SAPdb ID 1809 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row. SAPdb ID 1810 SAPdb ID 1811 SAPdb ID 1812 SAPdb ID 1813 SAPdb ID 1814
2
25564964 25775276
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly