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Peptide record

TPDB26317

Antibacterial Antifungal standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB26317
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 78-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
VVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKAGVIFTTKKGQQSCGDPKQEWVQRYMKNLDAKQKKASPRARAVA
Physicochemical Analysis
C385H632N114O108S6
H
K
8778.31
10.52
15
4
28
+11
16.72
-0.433
67.44
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
8730
99.45
25
Residue Composition
number
6
A
6
R
2
N
2
D
4
C
2
E
6
Q
3
G
0
H
3
I
3
L
9
K
2
M
3
F
5
P
8
S
3
T
1
W
2
Y
8
V
Amino Acid Distribution
A: 6 R: 6 N: 2 D: 2 C: 4 E: 2 Q: 6 G: 3 H: 0 I: 3 L: 3 K: 9 M: 2 F: 3 P: 5 S: 8 T: 3 W: 1 Y: 2 V: 8
Chemical Descriptors
78
C385H632N114O108S6
8778.31
10.52
+11
16.72
-0.433
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against the airway pathogens S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa (see the 2014 ref). The primary structure was reported in 1997 by Forssmann U and colleagues . Three C-terminal truncated variants with 73, 75, and 76 residues were isolated as well. NMR structure (73 residues) was solved in 2000 (go to the PDB link). You can rotate, zoom, and view the 3D structure here in the PDB . Reg 12/10/2014.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against the airway pathogens S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa (see the 2014 ref). The primary structure was reported in 1997 by Forssmann U and colleagues . Three C-terminal truncated variants with 73, 75, and 76 residues were isolated as well. NMR structure (73 residues) was solved in 2000 (go to the PDB link). You can rotate, zoom, and view the 3D structure here in the PDB . Reg 12/10/2014.