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Peptide record

TPDB26317

Antibacterial Antifungal standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB26317
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 78-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
VVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKAGVIFTTKKGQQSCGDPKQEWVQRYMKNLDAKQKKASPRARAVA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C385H632N114O108S6
H
K
8778.31
10.52
15
4
28
+11
2.00
-0.433
67.44
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
8730
0.99
25
Residue Composition
number
6
A
6
R
2
N
2
D
4
C
2
E
6
Q
3
G
0
H
3
I
3
L
9
K
2
M
3
F
5
P
8
S
3
T
1
W
2
Y
8
V
Amino Acid Distribution
A: 6 R: 6 N: 2 D: 2 C: 4 E: 2 Q: 6 G: 3 H: 0 I: 3 L: 3 K: 9 M: 2 F: 3 P: 5 S: 8 T: 3 W: 1 Y: 2 V: 8
Chemical Descriptors
78 reviewed residue count
C385H632N114O108S6 sequence-only estimate (linear, free termini)
8778.31 sequence-only estimate (linear, free termini)
10.52 sequence-only estimate (linear, free termini)
+11 sequence-only estimate (linear, free termini)
2.00 sequence-only estimate (linear, free termini)
-0.433 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against the airway pathogens S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa (see the 2014 ref). The primary structure was reported in 1997 by Forssmann U and colleagues . Three C-terminal truncated variants with 73, 75, and 76 residues were isolated as well. NMR structure (73 residues) was solved in 2000 (go to the PDB link). You can rotate, zoom, and view the 3D structure here in the PDB . Reg 12/10/2014.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against the airway pathogens S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa (see the 2014 ref). The primary structure was reported in 1997 by Forssmann U and colleagues . Three C-terminal truncated variants with 73, 75, and 76 residues were isolated as well. NMR structure (73 residues) was solved in 2000 (go to the PDB link). You can rotate, zoom, and view the 3D structure here in the PDB . Reg 12/10/2014.