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Peptide record

TPDB26316

Antibacterial Antifungal standard

31 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB26316

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.

Sequence

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

FASTA

>TPDB26316|Antibacterial;Antifungal|length=31
VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

Formula C131H222N36O40S6

Absent Amino Acids RNDEQWY

Common Amino Acids T

Mass 3133.78

PI 8.48

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +3

Boman Index 0.95

Hydrophobicity 0.571

Aliphatic Index 66.13

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 250

Absorbance 280nm 7.98

Polar Residues 13

number

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 5 E: 0 Q: 0 G: 4 H: 1 I: 2 L: 2 K: 3 M: 1 F: 1 P: 1 S: 2 T: 6 W: 0 Y: 0 V: 1

Length

Formula

C131H222N36O40S6

Mass

3133.78

8.48

Net Charge

Boman Index

0.95

Hydrophobicity

0.571

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.53 µM

Target

Target Organism Staphylococcus simulans 2B10

Source & Reference

Database Source NA

Other

Evidence Text

nM), E. faecium 4955 (MIC 260 nM), S. aureus 7016 (MIC 530 nM), S. capitis 20G (8.5 uM), S. simulans 2B10 (MIC 0.53 uM), S. epidermidis 99 (MIC 34 uM), L. gallinarum Lac43 (MIC 8.5 uM), L. frumenti Lac53 (MIC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 34 µM

Target

Target Organism Staphylococcus epidermidis 99

Source & Reference

Database Source NA

Other

Evidence Text

M), S. aureus 7016 (MIC 530 nM), S. capitis 20G (8.5 uM), S. simulans 2B10 (MIC 0.53 uM), S. epidermidis 99 (MIC 34 uM), L. gallinarum Lac43 (MIC 8.5 uM), L. frumenti Lac53 (MIC 1.06 uM), L. reuteri Lac54 (MIC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.5 µM

Target

Target Organism L. gallinarum Lac43

Source & Reference

Database Source NA

Other

Evidence Text

, S. capitis 20G (8.5 uM), S. simulans 2B10 (MIC 0.53 uM), S. epidermidis 99 (MIC 34 uM), L. gallinarum Lac43 (MIC 8.5 uM), L. frumenti Lac53 (MIC 1.06 uM), L. reuteri Lac54 (MIC 8.5 uM), L. paracasei LacR1 (MIC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.06 µM

Target

Target Organism L. frumenti Lac53

Source & Reference

Database Source NA

Other

Evidence Text

lans 2B10 (MIC 0.53 uM), S. epidermidis 99 (MIC 34 uM), L. gallinarum Lac43 (MIC 8.5 uM), L. frumenti Lac53 (MIC 1.06 uM), L. reuteri Lac54 (MIC 8.5 uM), L. paracasei LacR1 (MIC 17 uM), L. plantarum Lac 29 (MIC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.5 µM

Target

Target Organism L. reuteri Lac54

Source & Reference

Database Source NA

Other

Evidence Text

rmidis 99 (MIC 34 uM), L. gallinarum Lac43 (MIC 8.5 uM), L. frumenti Lac53 (MIC 1.06 uM), L. reuteri Lac54 (MIC 8.5 uM), L. paracasei LacR1 (MIC 17 uM), L. plantarum Lac 29 (MIC 1.06 uM), L. mucosae Lac28 (MIC

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 17 µM

Target

Target Organism L. paracasei LacR1

Source & Reference

Database Source NA

Other

Evidence Text

narum Lac43 (MIC 8.5 uM), L. frumenti Lac53 (MIC 1.06 uM), L. reuteri Lac54 (MIC 8.5 uM), L. paracasei LacR1 (MIC 17 uM), L. plantarum Lac 29 (MIC 1.06 uM), L. mucosae Lac28 (MIC 1.06 uM), L. reuteri Lac 56 (MI

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.06 µM

Target

Target Organism L. plantarum Lac 29

Source & Reference

Database Source NA

Other

Evidence Text

menti Lac53 (MIC 1.06 uM), L. reuteri Lac54 (MIC 8.5 uM), L. paracasei LacR1 (MIC 17 uM), L. plantarum Lac 29 (MIC 1.06 uM), L. mucosae Lac28 (MIC 1.06 uM), L. reuteri Lac 56 (MIC 69 uM), L. lactis NZ9800 (nisin A

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.06 µM

Target

Target Organism L. mucosae Lac28

Source & Reference

Database Source NA

Other

Evidence Text

ri Lac54 (MIC 8.5 uM), L. paracasei LacR1 (MIC 17 uM), L. plantarum Lac 29 (MIC 1.06 uM), L. mucosae Lac28 (MIC 1.06 uM), L. reuteri Lac 56 (MIC 69 uM), L. lactis NZ9800 (nisin A producer) (MIC 8.5 uM), S. uber

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 69 µM

Target

Target Organism L. reuteri Lac 56

Source & Reference

Database Source NA

Other

Evidence Text

sei LacR1 (MIC 17 uM), L. plantarum Lac 29 (MIC 1.06 uM), L. mucosae Lac28 (MIC 1.06 uM), L. reuteri Lac 56 (MIC 69 uM), L. lactis NZ9800 (nisin A producer) (MIC 8.5 uM), S. uberis strain 42 (nisin U) (MIC 4.2

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.53 µM

Target

Target Organism Staphylococcus simulans 2B10

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 34 µM

Target

Target Organism Staphylococcus epidermidis 99

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.5 µM

Target

Target Organism L. gallinarum Lac43

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.06 µM

Target

Target Organism L. frumenti Lac53

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.5 µM

Target

Target Organism L. reuteri Lac54

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 17 µM

Target

Target Organism L. paracasei LacR1

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.06 µM

Target

Target Organism L. plantarum Lac 29

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.06 µM

Target

Target Organism L. mucosae Lac28

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 69 µM

Target

Target Organism L. reuteri Lac 56

Source & Reference

Database Source Antifungipept

Other

Evidence Text