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Peptide record

TPDB26261

Antibacterial Anticancer Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB26261
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
VRRFXWWWXFLRR
Physicochemical Analysis
C86H118N26O12
ANDCEQGHIKMPSTY
R
1708.05
12.88
4
0
7
+4
-5.06
-0.546
52.31
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
966.01
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C86H118N26O12
1708.05
12.88
+4
-5.06
-0.546
Evidence Records 8 records
Evidence 1 Activity

Activity

IC50
Toxicity
52 µM
Cytotoxic
IC50 | 52 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 2 Activity

Activity

32% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
32% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 3 Activity

Activity

48% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
48% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 4 Activity

Activity

IC50
Toxicity
48 µM
Cytotoxic
IC50 | 48 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 5 Activity

Activity

55% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
55% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 6 Activity

Activity

68% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
68% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 7 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 8 Activity

Activity

0% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
0% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006