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Peptide record

TPDB26217

Antibacterial Anticancer Antifungal Toxicity standard
52 amino acids
Basic Information
3D PDB MODEL
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TPDB26217
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 52-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.
Sequence
VPAESEAAHLRVRRGFGCPLNQGACHNHCRSIRRRGGYCSGIIKQTCTCYRN
Physicochemical Analysis
C240H390N88O69S6
DMW
R
5804.64
9.70
12
2
14
+7
11.40
-0.606
56.35
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
3355
57.80
18
Residue Composition
number
4
A
8
R
3
N
0
D
6
C
2
E
2
Q
6
G
3
H
3
I
2
L
1
K
0
M
1
F
2
P
3
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 4 R: 8 N: 3 D: 0 C: 6 E: 2 Q: 2 G: 6 H: 3 I: 3 L: 2 K: 1 M: 0 F: 1 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
52
C240H390N88O69S6
5804.64
9.70
+7
11.40
-0.606
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

B. pumilus CMCC63202

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ B. pumilus CMCC63202 (MIC 1 uM), S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistan
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus aureus CMCC26003

Source & Reference

dbAMP

Other

Active against Gram+ B. pumilus CMCC63202 (MIC 1 uM), S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistant M. bovis (MIC 20 uM), Gram- S-t
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

M. luteus CMCC63202

Source & Reference

dbAMP

Other

Active against Gram+ B. pumilus CMCC63202 (MIC 1 uM), S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistant M. bovis (MIC 20 uM), Gram- S-typhimurium CVCC542 (MIC > 50 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
20 µM

Target

M. bovis

Source & Reference

dbAMP

Other

S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistant M. bovis (MIC 20 uM), Gram- S-typhimurium CVCC542 (MIC > 50 uM), P-aeruginosa CVCC2000 (MIC > 50 uM), E. coli,
Evidence 5 Activity

Activity

MIC
Antifungal
1 µM

Target

B. pumilus CMCC63202

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ B. pumilus CMCC63202 (MIC 1 uM), S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistan
Evidence 6 Activity

Activity

MIC
Antifungal
20 µM

Target

Staphylococcus aureus CMCC26003

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. pumilus CMCC63202 (MIC 1 uM), S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistant M. bovis (MIC 20 uM), Gram- S-t
Evidence 7 Activity

Activity

MIC
Antifungal
50 µM

Target

M. luteus CMCC63202

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. pumilus CMCC63202 (MIC 1 uM), S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistant M. bovis (MIC 20 uM), Gram- S-typhimurium CVCC542 (MIC > 50 uM),
Evidence 8 Activity

Activity

MIC
Antifungal
20 µM

Target

M. bovis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. aureus CMCC26003 (MIC 20 uM), M. luteus CMCC63202 (MIC 50 uM), carbenicillin-resistant M. bovis (MIC 20 uM), Gram- S-typhimurium CVCC542 (MIC > 50 uM), P-aeruginosa CVCC2000 (MIC > 50 uM), E. coli,
Evidence 9 Activity

Activity

0% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
0% Hemolysis | 10 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization of a defensin gene from a hard tick, Dermacentor silvarum. | Parasit Vectors | 2015
Evidence 10 Activity

Activity

2% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
2% Hemolysis | 20 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization of a defensin gene from a hard tick, Dermacentor silvarum. | Parasit Vectors | 2015
Evidence 11 Activity

Activity

7% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
7% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization of a defensin gene from a hard tick, Dermacentor silvarum. | Parasit Vectors | 2015
Evidence 12 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Molecular characterization of a defensin gene from a hard tick, Dermacentor silvarum. | Parasit Vectors | 2015