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Peptide record

TPDB26163

Anti-inflammatory Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB26163
Anti-inflammatory Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VLGLALIVGGALLIKKKQAKS
Physicochemical Analysis
C99H182N26O24
RNDCEHMFPTWY
L
2120.69
11.00
4
0
12
+4
0.91
0.986
171.90
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
1
Q
3
G
0
H
2
I
5
L
4
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 2 L: 5 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C99H182N26O24
2120.69
11.00
+4
0.91
0.986
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

Enterococcus faecalis JH2-2

Source & Reference

NA

Other

Active against S. aureus ATCC 33591 or USA300 (MRSA, MIC 32 ug/ml), E.faecalis JH2-2 (MIC 128 ug/ml), L.monocytogenes (MIC 512 ug/ml), K.pneumoniae (MIC 512 ug/ml or higher), A. baumannii se
Evidence 2 Activity

Activity

MIC
Antibacterial
512 µg/mL

Target

L.monocytogenes

Source & Reference

NA

Other

st S. aureus ATCC 33591 or USA300 (MRSA, MIC 32 ug/ml), E.faecalis JH2-2 (MIC 128 ug/ml), L.monocytogenes (MIC 512 ug/ml), K.pneumoniae (MIC 512 ug/ml or higher), A. baumannii sensitive (MIC 32-64 ug/ml), A.baum
Evidence 3 Activity

Activity

MIC
Antibacterial
32-64 µg/mL

Target

A. baumannii sensitive

Source & Reference

NA

Other

(MIC 128 ug/ml), L.monocytogenes (MIC 512 ug/ml), K.pneumoniae (MIC 512 ug/ml or higher), A. baumannii sensitive (MIC 32-64 ug/ml), A.baumannii IMI, MER, OXA-23, OXA-50 (MIC 64-128 ug/ml), E.coli (MIC 512 ug/ml), S.typhi
Evidence 4 Activity

Activity

MIC
Antibacterial
512 µg/mL

Target

E.coli

Source & Reference

NA

Other

nii sensitive (MIC 32-64 ug/ml), A.baumannii IMI, MER, OXA-23, OXA-50 (MIC 64-128 ug/ml), E.coli (MIC 512 ug/ml), S.typhimurium, B.cereus (MIC 256 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginos
Evidence 5 Activity

Activity

MIC
Antibacterial
256 µg/mL

Target

B.cereus

Source & Reference

NA

Other

annii IMI, MER, OXA-23, OXA-50 (MIC 64-128 ug/ml), E.coli (MIC 512 ug/ml), S.typhimurium, B.cereus (MIC 256 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginosa AMT0060 (CF) (MIC 256 ug/ml), P. aerugi
Evidence 6 Activity

Activity

MIC
Antibacterial
>512 µg/mL

Target

P.aeruginosa PAO1

Source & Reference

NA

Other

A-50 (MIC 64-128 ug/ml), E.coli (MIC 512 ug/ml), S.typhimurium, B.cereus (MIC 256 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginosa AMT0060 (CF) (MIC 256 ug/ml), P. aeruginosa C3719 or LES400 (MIC 64 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Pseudomonas aeruginosa C3719 or LES400

Source & Reference

NA

Other

56 ug/ml), P.aeruginosa PAO1 (MIC >512 ug/ml), P.aeruginosa AMT0060 (CF) (MIC 256 ug/ml), P. aeruginosa C3719 or LES400 (MIC 64 ug/ml).
Evidence 8 Activity

Activity

IC50
Toxicity
294±42 µg/mL
Cytotoxic
IC50 | 294±42 | µg/mL | target cell: Human Lung Fibroblasts IMR-90

Target

Human Lung Fibroblasts IMR-90

Source & Reference

NA
DBAASP
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. | NPJ Biofilms Microbiomes | 2022
Evidence 9 Activity

Activity

IC50
Toxicity
>1000 µg/mL
Cytotoxic
IC50 | >1000 | µg/mL | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. | NPJ Biofilms Microbiomes | 2022
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
458±101 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 458±101 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus. | NPJ Biofilms Microbiomes | 2022
Evidence 11 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
NPJ Biofilms Microbiomes. 2022 Jul 14 8(1):59.