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Peptide record

TPDB26149

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Antihypertensive Bitter iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB26149
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Antihypertensive Bitter iDPPIV
Anti-infective peptides Cardiometabolic peptides Food sensory peptides
Peptipedia AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Antihypertensive, Bitter, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
VL
Physicochemical Analysis
C11H22N2O3
ARNDCEQGHIKMFPSTWY
LV
230.31
6.02
0
0
2
-0
-0.49
4.000
340.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
2
C11H22N2O3
230.31
6.02
-0
-0.49
4.000
230.3031
230.1625
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
iDPPIV
74.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)C(C)C InChI=1S/C11H22N2O3/c1-6(2)5-8(11(15)16)13-10(14)9(12)7(3)4/h6-9H,5,12H2,1-4H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1 InChIKey: XCTHZFGSVQBHBW-IUCAKERBSA-N Peptide found in whey protein hydrolysate: Morifuji M., Koga J., Kawanaka K., Higuchi M., 2009, Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake in L6 myotubes and isolated skeletal muscles. J. Nutr. Sci. Vitaminol., 55, 81-86 Le Maux S., Nongonierma A. B., Murray B., Kelly P. M., FitzGerald R. J., 2015, Identification of short peptide sequences in the nanofiltration permeate of a bioactive whey protein hydrolysate. Food Res. Int., 77, 534-539. Glucose uptake stimulating activity according to the BIOPEP-UWM database of bioactive peptides (ID 8320) Inhibitor of citrulline uptake in yeasts according to the ChEMBL database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the PlantPepDB database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 110) the ChEMBL database
Additional Detail Fields 1 fields
2