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Peptide record

TPDB26134

Antibacterial Anticancer Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB26134
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
VKAWAKVLKGFGKLLKGFGKL
Physicochemical Analysis
C113H186N28O22
RNDCEQHIMPSTY
K
2288.89
11.21
6
0
11
+6
-0.57
0.329
111.43
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
240.29
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
0
I
4
L
6
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 4 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21
C113H186N28O22
2288.89
11.21
+6
-0.57
0.329
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Toxicity
9.1 µM
Cytotoxic
EC50 | 9.1 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
113±4 µM
Hemolytic Cytotoxic
50% Hemolysis | 113±4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1682.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis