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Peptide record

TPDB26108

Antibacterial Anticancer Toxicity standard

22 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB26108

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 22-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

VGALAGFLYWHFLRKGTKMVGK

FASTA

>TPDB26108|Antibacterial;Anticancer;Toxicity|length=22
VGALAGFLYWHFLRKGTKMVGK

Formula C119H183N31O25S1

Absent Amino Acids NDCEQIPS

Common Amino Acids G

Mass 2480.01

PI 10.91

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +4

Boman Index -2.24

Hydrophobicity 0.318

Aliphatic Index 88.64

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 281.85

Polar Residues 2

number

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 3 K: 3 M: 1 F: 2 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 2

Length

Formula

C119H183N31O25S1

Mass

2480.01

10.91

Net Charge

Boman Index

-2.24

Hydrophobicity

0.318

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µM

Target

Target Organism B. subtilis 168HT

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. subtilis 168HT (MIC 1.6 uM), S.aureus ST 88 (MIC >100 uM), S.hemolyticus 527 (MIC >100 uM), M.smegmatis (MIC >100 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.aureus ST 88

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. subtilis 168HT (MIC 1.6 uM), S.aureus ST 88 (MIC >100 uM), S.hemolyticus 527 (MIC >100 uM), M.smegmatis (MIC >100 uM), Gram- E. coli MG1655 (MIC 12

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.hemolyticus 527

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. subtilis 168HT (MIC 1.6 uM), S.aureus ST 88 (MIC >100 uM), S.hemolyticus 527 (MIC >100 uM), M.smegmatis (MIC >100 uM), Gram- E. coli MG1655 (MIC 12.9 uM), K.pneumonia 148 (MIC >100

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism M.smegmatis

Source & Reference

Database Source NA

Other

Evidence Text

btilis 168HT (MIC 1.6 uM), S.aureus ST 88 (MIC >100 uM), S.hemolyticus 527 (MIC >100 uM), M.smegmatis (MIC >100 uM), Gram- E. coli MG1655 (MIC 12.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.9 µM

Target

Target Organism Escherichia coli MG1655

Source & Reference

Database Source NA

Other

Evidence Text

us ST 88 (MIC >100 uM), S.hemolyticus 527 (MIC >100 uM), M.smegmatis (MIC >100 uM), Gram- E. coli MG1655 (MIC 12.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 or 231 (M

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism K.pneumonia 148

Source & Reference

Database Source NA

Other

Evidence Text

lyticus 527 (MIC >100 uM), M.smegmatis (MIC >100 uM), Gram- E. coli MG1655 (MIC 12.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 or 231 (MIC >100 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism K.pneumonia 50

Source & Reference

Database Source NA

Other

Evidence Text

egmatis (MIC >100 uM), Gram- E. coli MG1655 (MIC 12.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 or 231 (MIC >100 uM).

Evidence 8 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022

Evidence 9 Activity

Activity

Activity Endpoint LC90

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC90 | 50 | µM | target cell: Mouse fibroblasts McCoy

Target

Target Cell Mouse fibroblasts McCoy

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022

Evidence 10 Activity

Activity

Activity Endpoint LC90

Detail Source Activity Toxicity

Activity Measurement <25 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC90 | <25 | µM | target cell: Human primary fibroblasts FF1

Target

Target Cell Human primary fibroblasts FF1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022

Evidence 11 Activity

Activity

Activity Endpoint LC90

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC90 | 100 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022