Back to search

Peptide record

TPDB26106

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Peptide 1 ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Umami iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB26106
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Peptide 1
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Umami iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Food sensory peptides Self-assembling and biomaterial peptides
FermFooDB Peptipedia SATPdb CAFPdb AHTPDB AHTpin Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from FermFooDB, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
VG
Physicochemical Analysis
C7H14N2O3
ARNDCEQHILKMFPSTWY
GV
174.20
6.02
0
0
1
-0
0.08
1.900
145.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
2
C7H14N2O3
174.20
6.02
-0
0.08
1.900
174.1971
174.1001
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

21833387
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanosphere Spherical structure
pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
Selfassembly; Nanostructure=Nanosphere; Spherical structure; Trigger=pH: 6.96; temperature: 37 °C; solvent: Water; concentration: 0.06mmol
FE - SEM (Field Emission Scanning Electron Microscopy), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1100.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)NCC(=O)O InChI=1S/C7H14N2O3/c1-4(2)6(8)7(12)9-3-5(10)11/h4,6H,3,8H2,1-2H3,(H,9,12)(H,10,11)/t6-/m0/s1 InChIKey: IOUPEELXVYPCPG-LURJTMIESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8918) Inhibitor of citrulline uptake in yeasts according to the ChEMBL database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 258) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 329) the ChEMBL database
Evidence 2 Activity

Activity

IC50
Antihypertensive
1100.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)NCC(=O)O InChI=1S/C7H14N2O3/c1-4(2)6(8)7(12)9-3-5(10)11/h4,6H,3,8H2,1-2H3,(H,9,12)(H,10,11)/t6-/m0/s1 InChIKey: IOUPEELXVYPCPG-LURJTMIESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8918) Inhibitor of citrulline uptake in yeasts according to the ChEMBL database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 258) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 329) the ChEMBL database
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)NCC(=O)O InChI=1S/C7H14N2O3/c1-4(2)6(8)7(12)9-3-5(10)11/h4,6H,3,8H2,1-2H3,(H,9,12)(H,10,11)/t6-/m0/s1 InChIKey: IOUPEELXVYPCPG-LURJTMIESA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides the BRENDA database the ChEMBL database Inhibitor of citrulline uptake in yeasts according to the ChEMBL database Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 258) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 329) the ChEMBL database
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanosphere Spherical structure Trigger=pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
Nanosphere Spherical structure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
FE - SEM (Field Emission Scanning Electron Microscopy), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
21833387
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 6.96 temperature: 37 °C solvent: Water concentration: 0.06mmol
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
21833387
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly