TPDB

3D PDB MODEL

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TPDB ID TPDB26065

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 19-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Modification

Modified, details unspecified

Sequence

VDKPPYLPRPRPXRXXYNX

FASTA

>TPDB26065|Antibacterial;Anticancer;Toxicity|length=19
VDKPPYLPRPRPXRXXYNX

Formula C86H134N26O21

Absent Amino Acids ACEQGHIMFSTW

Common Amino Acids P

Mass 1868.17

PI 10.58

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 4

Net Charge +3

Boman Index 4.95

Hydrophobicity -1.421

Aliphatic Index 35.79

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 159.51

Polar Residues 3

number

0

A

3

R

1

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

5

P

0

S

0

T

0

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 5 S: 0 T: 0 W: 0 Y: 2 V: 1

Length

19

Formula

C86H134N26O21

Mass

1868.17

PI

10.58

Net Charge

+3

Boman Index

4.95

Hydrophobicity

-1.421

Evidence 1 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex. | Chembiochem | 2011

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex. | Chembiochem | 2011

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: Not active up to 600 µg/ml | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Chembiochem. 2011 Apr 11 12(6):874-6.