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Peptide record

TPDB25999

ACE inhibitor ACE inhibitor (fr. of alpha s1-casein, 194-199) ACE inhibitors Antibacterial Antifungal Antihypertensive Neuropeptide standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB25999
ACE inhibitor ACE inhibitor (fr. of alpha s1-casein, 194-199)
ACE inhibitors Antibacterial Antifungal Antihypertensive Neuropeptide
Anti-infective peptides Cardiometabolic peptides Neuroactive peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
TTMPLW
Physicochemical Analysis
C35H53N7O9S1
ARNDCEQGHIKFSYV
T
747.91
6.02
0
0
3
-0
-1.91
0.300
65.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
735.39
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
0
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
6
C35H53N7O9S1
747.91
6.02
-0
-1.91
0.300
747.9008
747.3613
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
16.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Maruyama S., Mitachi H., Awaya J., Kurono M., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitory activity of the C-terminal hexapeptide of αs1-casein. Agric. Biol. Chem., 51, 2557-2561, 1987
1987
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC1=CNC2=C1C=CC=C2)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCSC)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)[C@@H](C)O)[C@@H](C)O)C(O)=O InChI=1S/C35H53N7O9S/c1-18(2)15-25(30(45)40-26(35(50)51)16-21-17-37-23-10-7-6-9-22(21)23)39-31(46)27-11-8-13-42(27)34(49)24(12-14-52-5)38-33(48)29(20(4)44)41-32(47)28(36)19(3)43/h6-7,9-10,17-20,24-29,37,43-44H,8,11-16,36H2,1-5H3,(H,38,48)(H,39,46)(H,40,45)(H,41,47)(H,50,51)/t19-,20-,24+,25+,26+,27+,28+,29+/m1/s1 InChIKey=QGGBSIAUWWUJLC-QAPARMCSSA-N Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8172) the EROP-Moscow database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3127) the MBPDB database Antifungal peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9619) the mBPDB database
Evidence 2 Activity

Activity

IC50
ACE inhibitors
905.43 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Zhang Z., Shu G., Nan J., Meng F., Zhang M., Chen L.
Exploring the healthy potential of goat milk fermented by novel isolated lactic acid bacteria: Genetic identification, bioactive peptides, nutritional mechanism and sensory evaluation. Int. J. Food Microbiol., 442, 111354, 2025
2025
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C32H42N6O10/c33-14-8-7-13-22(32(47)48)35-30(45)24(17-26(39)40)38-31(46)25(18-27(41)42)37-29(44)23(16-20-11-5-2-6-12-20)36-28(43)21(34)15-19-9-3-1-4-10-19/h1-6,9-12,21-25H,7-8,13-18,33-34H2,(H,35,45)(H,36,43)(H,37,44)(H,38,46)(H,39,40)(H,41,42)(H,47,48)/t21-,22-,23-,24-,25-/m0/s1 InChIKey=VNFLYRBAHMJSJE-KEOOTSPTSA-N
Evidence 3 Activity

Activity

IC50
Antihypertensive
16.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Maruyama S., Mitachi H., Awaya J., Kurono M., Tomizuka N., Suzuki H.
Angiotensin I-converting enzyme inhibitory activity of the C-terminal hexapeptide of αs1-casein. Agric. Biol. Chem., 51, 2557-2561, 1987
1987
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC1=CNC2=C1C=CC=C2)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CCSC)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)[C@@H](C)O)[C@@H](C)O)C(O)=O InChI=1S/C35H53N7O9S/c1-18(2)15-25(30(45)40-26(35(50)51)16-21-17-37-23-10-7-6-9-22(21)23)39-31(46)27-11-8-13-42(27)34(49)24(12-14-52-5)38-33(48)29(20(4)44)41-32(47)28(36)19(3)43/h6-7,9-10,17-20,24-29,37,43-44H,8,11-16,36H2,1-5H3,(H,38,48)(H,39,46)(H,40,45)(H,41,47)(H,50,51)/t19-,20-,24+,25+,26+,27+,28+,29+/m1/s1 InChIKey=QGGBSIAUWWUJLC-QAPARMCSSA-N Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8172) the EROP-Moscow database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3127) the MBPDB database Antifungal peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9619) the mBPDB database
Evidence 4 Activity

Activity

IC50
Antihypertensive
905.43 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Zhang Z., Shu G., Nan J., Meng F., Zhang M., Chen L.
Exploring the healthy potential of goat milk fermented by novel isolated lactic acid bacteria: Genetic identification, bioactive peptides, nutritional mechanism and sensory evaluation. Int. J. Food Microbiol., 442, 111354, 2025
2025
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C32H42N6O10/c33-14-8-7-13-22(32(47)48)35-30(45)24(17-26(39)40)38-31(46)25(18-27(41)42)37-29(44)23(16-20-11-5-2-6-12-20)36-28(43)21(34)15-19-9-3-1-4-10-19/h1-6,9-12,21-25H,7-8,13-18,33-34H2,(H,35,45)(H,36,43)(H,37,44)(H,38,46)(H,39,40)(H,41,42)(H,47,48)/t21-,22-,23-,24-,25-/m0/s1 InChIKey=VNFLYRBAHMJSJE-KEOOTSPTSA-N
Additional Detail Fields 1 fields
6