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Peptide record

TPDB25969

Antibacterial Antifungal Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB25969
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 7-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
TRKKWFW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C53H74N14O9
ANDCEQGHILMPSYV
KW
1051.26
11.64
3
0
3
+3
2.99
-1.714
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
11000
10.46
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
1
F
0
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
7 reviewed residue count
C53H74N14O9 sequence-only estimate (linear, free termini)
1051.26 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
2.99 sequence-only estimate (linear, free termini)
-1.714 sequence-only estimate (linear, free termini)
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

P. digitatum PHI-26

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against P. digitatum PHI-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

P. italicum PHI-1

Source & Reference

dbAMP

Other

active against P. digitatum PHI-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

P. expansum PHI-65

Source & Reference

dbAMP

Other

active against P. digitatum PHI-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

p. PHI-44

Source & Reference

dbAMP

Other

I-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

A. nidulans biA1

Source & Reference

dbAMP

Other

alicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM),
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

F. oxysporum CECT2866

Source & Reference

dbAMP

Other

Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM
Evidence 7 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli DH5alpha

Source & Reference

dbAMP

Other

, B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM), and S. cerevisiae FY1679 (MIC 32 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. subtilis CECT498

Source & Reference

dbAMP

Other

oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM), and S. cerevisiae FY1679 (MIC 32 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. cerevisiae FY1679

Source & Reference

dbAMP

Other

sea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM), and S. cerevisiae FY1679 (MIC 32 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

P. digitatum PHI-26

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against P. digitatum PHI-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

P. italicum PHI-1

Source & Reference

dbAMP CAFPdb

Other

active against P. digitatum PHI-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8
Evidence 12 Activity

Activity

MIC
Antifungal
8 µM

Target

P. expansum PHI-65

Source & Reference

dbAMP CAFPdb

Other

active against P. digitatum PHI-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
8 µM

Target

p. PHI-44

Source & Reference

dbAMP CAFPdb

Other

I-26 (MIC 8 uM), P. italicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM),
Evidence 14 Activity

Activity

MIC
Antifungal
8 µM

Target

A. nidulans biA1

Source & Reference

dbAMP CAFPdb

Other

alicum PHI-1 (MIC 4 uM), P. expansum PHI-65 (MIC 8 uM), Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM),
Evidence 15 Activity

Activity

MIC
Antifungal
8 µM

Target

F. oxysporum CECT2866

Source & Reference

dbAMP CAFPdb

Other

Alternaria sp. PHI-44 (MIC 8 uM), A. nidulans biA1 (MIC 8 uM), B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM
Evidence 16 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli DH5alpha

Source & Reference

dbAMP CAFPdb

Other

, B. cinerea #8 (MIC 8 uM), F. oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM), and S. cerevisiae FY1679 (MIC 32 uM).
Evidence 17 Activity

Activity

MIC
Antifungal
16 µM

Target

B. subtilis CECT498

Source & Reference

dbAMP CAFPdb

Other

oxysporum CECT2866 (MIC 8 uM), M-grisea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM), and S. cerevisiae FY1679 (MIC 32 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
32 µM

Target

S. cerevisiae FY1679

Source & Reference

dbAMP CAFPdb

Other

sea PR-9 (MIC >32 uM), E. coli DH5alpha (MIC 32 uM), B. subtilis CECT498 (MIC 16 uM), and S. cerevisiae FY1679 (MIC 32 uM).