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Peptide record

TPDB25965

Antibacterial Antifungal standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB25965
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 71-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
TRGSDISKTCCFQYSHKPLPWTWVRSYEFTSNSCSQRAVIFTTKRGKKVCTHPRKKWVQKYISLLKTPKQL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C379H598N108O100S4
M
K
8395.82
10.62
17
2
21
+13
2.21
-0.739
56.20
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
21220
2.53
28
Residue Composition
number
1
A
5
R
1
N
1
D
4
C
1
E
4
Q
2
G
2
H
3
I
4
L
10
K
0
M
3
F
4
P
8
S
8
T
3
W
3
Y
4
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 1 C: 4 E: 1 Q: 4 G: 2 H: 2 I: 3 L: 4 K: 10 M: 0 F: 3 P: 4 S: 8 T: 8 W: 3 Y: 3 V: 4
Chemical Descriptors
71 reviewed residue count
C379H598N108O100S4 sequence-only estimate (linear, free termini)
8395.82 sequence-only estimate (linear, free termini)
10.62 sequence-only estimate (linear, free termini)
+13 sequence-only estimate (linear, free termini)
2.21 sequence-only estimate (linear, free termini)
-0.739 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against the airway pathogens S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. NMR structure was solved in 2001 ( Ye J et al., 2001 ). You can rotate, zoom, and view the 3D structure here in the PDB . Reg 12/10/2014.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against the airway pathogens S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. NMR structure was solved in 2001 ( Ye J et al., 2001 ). You can rotate, zoom, and view the 3D structure here in the PDB . Reg 12/10/2014.