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Peptide record

TPDB25964

Antibacterial Toxicity modified_plain modified
27 amino acids
Basic Information
3D PDB MODEL
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TPDB25964
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 27-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
TRAQWFAIQHISXSTIAMRAINNYRWR
Physicochemical Analysis
C143H220N46O36S1
DCEGLKPV
ARI
3191.67
12.40
5
0
13
+4
-1.18
-0.422
72.59
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
12490
391.33
9
Residue Composition
number
4
A
4
R
2
N
0
D
0
C
0
E
2
Q
0
G
1
H
4
I
0
L
0
K
1
M
1
F
0
P
2
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 4 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 4 L: 0 K: 0 M: 1 F: 1 P: 0 S: 2 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
27
C143H220N46O36S1
3191.67
12.40
+4
-1.18
-0.422
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
7.3±0.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 7.3±0.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. | J Med Chem | 2011