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Peptide record

TPDB25946

Antibacterial standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB25946
Antibacterial
Anti-infective peptides
Peptipedia
standard
No
A 12-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
TRSGFLREQWIT
Physicochemical Analysis
C67H104N20O19
ANDCHKMPYV
RT
1493.69
10.89
2
1
4
+1
0.79
-0.700
65.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
368.22
4
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
1
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C67H104N20O19
1493.69
10.89
+1
0.79
-0.700
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Staphylococcus aureus MRSA

Source & Reference

NA

Other

Active against S. aureus MRSA (MIC 4 ug/ml), methicillin-susceptible S. aureus (MSSA) (MIC 1-4 ug/ml), lab-generated vancomycin-resis
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

hicillin-susceptible S. aureus (MSSA) (MIC 1-4 ug/ml), lab-generated vancomycin-resistant S. aureus (MIC 8 ug/ml), Bacillus spp. (MIC 2 ug/ml), L. monocytogenes (MIC 1 ug/ml), and Mycobacterium spp. (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

L. monocytogenes

Source & Reference

NA

Other

lab-generated vancomycin-resistant S. aureus (MIC 8 ug/ml), Bacillus spp. (MIC 2 ug/ml), L. monocytogenes (MIC 1 ug/ml), and Mycobacterium spp. (MIC 8 ug/ml). Inactive against E.coli, P.aeruginosa, S.marcescen