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Peptide record

TPDB25945

Antibacterial Toxicity standard

22 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB25945

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

TRRKWWKKVLNGAIKIAPYILD

FASTA

>TPDB25945|Antibacterial;Toxicity|length=22
TRRKWWKKVLNGAIKIAPYILD

Formula C127H205N35O28

Absent Amino Acids CEQHMFS

Common Amino Acids K

Mass 2670.24

PI 11.02

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +5

Boman Index 0.87

Hydrophobicity -0.386

Aliphatic Index 110.91

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 12490

Absorbance 280nm 467.75

Polar Residues 3

number

Amino Acid Distribution

A: 2 R: 2 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 4 M: 0 F: 0 P: 1 S: 0 T: 1 W: 2 Y: 1 V: 1

Length

Formula

C127H205N35O28

Mass

2670.24

11.02

Net Charge

Boman Index

0.87

Hydrophobicity

-0.386

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E-faecium (MIC >64 uM), S. aureus (MIC 1 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloa

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E-faecium (MIC >64 uM), S. aureus (MIC 1 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (M

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source NA

Other

Evidence Text

Active against E-faecium (MIC >64 uM), S. aureus (MIC 1 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 4 uM), S. Typhimurium (M

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

MIC >64 uM), S. aureus (MIC 1 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 0.5 uM), and P. vulgari

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

C 1 uM), K. pneumoniae (MIC 0.5 uM), A. baumannii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 0.5 uM), and P. vulgaris (MIC 8 uM). Also inhibi

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

IC 0.5 uM), A. baumannii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 0.5 uM), and P. vulgaris (MIC 8 uM). Also inhibit biofilm formation.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source NA

Other

Evidence Text

nnii (MIC 0.5 uM), P. aeruginosa (MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 0.5 uM), and P. vulgaris (MIC 8 uM). Also inhibit biofilm formation.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism P. vulgaris

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 1 uM), E. cloacae (MIC 0.5 uM), E. coli (MIC 4 uM), S. Typhimurium (MIC 0.5 uM), and P. vulgaris (MIC 8 uM). Also inhibit biofilm formation.

Evidence 9 Activity

Activity

Activity Endpoint 45% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

45% Cytotoxicity | 10 | µM | target cell: Human bronchial epithelial cells 16HBE14o-

Target

Target Cell Human bronchial epithelial cells 16HBE14o-

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022

Evidence 10 Activity

Activity

Activity Endpoint 45% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Cytotoxic

Toxicity Raw

45% Cytotoxicity | 10 | µM | target cell: Human PBMC

Target

Target Cell Human PBMC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. | Antibiotics (Basel) | 2022